Some common heterocyclic compound, 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1996-29-8
Under an argon atmosphere,9H-carbazole (9.3 g), 1-bromo-4-chloro-2-fluorobenzene (23.3 g), cesium carbonate (36.2 g) and DMF (222 mL) were stirred at 150 C. for 7 hours. Water was added at room temperature, and the resulting mixture was extracted with ethyl acetate. The organic layer was purified by silica gel chromatography, and the solvent was removed to obtain 9- (2-bromo-5-chlorophenyl) carbazole as a white solid (11.4 g, yield 58%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1996-29-8, its application will become more common.
Reference:
Patent; IDEMITSU KOSAN COMPANY LIMITED; HAKETA, TASUKU; ITO, HIROKATSU; KUDO, YU; (149 pag.)JP2018/108939; (2018); A;,
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