In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201849-21-0, name is 4-Bromo-2-chloro-1-isopropoxybenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C9H10BrClO
DESCRIPTION FOR D692-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (D69)To a suspension of 4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene (D68) (10 g), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-1,3,2-dioxaborolane (15.26 g) and potassium acetate (15.73 g) in N,N-dimethylformamide (DMF) (150 mL) stirred under nitrogen at room temperature was added PdCl2(dppf)-CH2Cl2 adduct (1.964 g). The reaction mixture was stirred at 80 C. overnight. After cooling the reaction, the reaction mixture was concentrated in vacuo, the residue was diluted with ethyl acetate and filtered through celite, the filtrate was washed with water and brine, the organic phase was dried over anhydrous Na2SO4. After removing the solvent, the residue was purified by column chromatography to give 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (D69) (11.8 g). MS (ES): C15H22BClO3 requires 296. found 297.1 (M+H+).
The synthetic route of 201849-21-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Glaxo Group Limited; US2011/269738; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics