Electric Literature of 62356-27-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62356-27-8, name is 1-Bromo-3-chloro-2-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 35; STEP A; A reaction mixture of 1-bromo-3-chloro-2-methylbenzene (1.03 g, 5 mmol), methyl but-2-enoate (583 mul_, 5.5 mmol), Pd2(DBA)3 (137.4 mg, 0.15 mmol), tri-f-butylphosphonium tetrafluoroborate (87 mg, 0.3 mmol) and N, N- dicyclohexylmethylamine (1.27 ml_, 6 mmol) in dioxane (5 ml_) was stirred at room temperature under an atmosphere of argon for overnight. Some precipitates formed. The reaction mixture was filtered, and concentrated. Column chromatography with an eluent of 10% EtOAc in Hexane gave compound 35-1 as yellow oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-chloro-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann; WO2010/56631; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics