In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4584-46-7 as follows. HPLC of Formula: C4H11Cl2N
A mixture of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenol (0.22 g, 1 .00 mmol), 2-chloro-N,N-dimethylethanamine hydrochloride (0.17 g, 1.15 mmol) and cesium carbonate (1.3 g, 4.00 mmol) in tetrahydrofuran (4 mL) was heated at 130 00 for 2 hours under microwave irradiation. After cooling to room temperature the reactionmixture was partitioned between water and ethyl acetate. The organic phase was separated, washed with additional water and brine, dried over sodium sulfate and thesolvent was evaporated to dryness to yield the title compound (254 mg, 86%) as a brownish oil.LRMS (mlz): 291 (M+1).1H-NMR (300 MHz, CDCI3): 1.3 (s, 12H), 2.3 (s, 6H), 2.7 (t, 2H), 4.1 (t, 2H),6.8 – 7.0 (d, 2H), 7.6 – 7.9 (d, 2H).
According to the analysis of related databases, 4584-46-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALMIRALL, S.A.; BACH TANA, Jordi; PEREZ CRESPO, Daniel; LLERA SOLDEVILA, Oriol; ESTEVE TRIAS, Cristina; TABOADA MARTINEZ, Lorena; WO2015/86693; (2015); A1;,
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