Related Products of 4584-46-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4584-46-7 as follows.
Me2N(CH2)2Cl.HCl (1.77 g, 12 mmol), K2CO3(3.40 g, 25 mmol) and water (8 mL) were added to 31 (1.68 g, 8.2 mmol)in CHCl3 (40 mL). The stirred solution was placed in an oil bath at65C. The temperature was slowly raised to 80C during 65 min and themixture was stirred for 16 h at 80C. The organic phase was separated and thesolvent was evaporated to 25% of its original volume. This solution was combinedwith the aqueous phase and diluted with water and toluene. The organic layerwas separated, washed with water and extracted with aq. HCl (1.0 M). The acidicphase was washed (toluene), cooled to 0C, basified (~pH 12) by addition ofaq. NaOH (4.0 M) and extracted (toluene). The extract was washed (water,brine) and dried. Evaporation gave 32 (1.81 g, 80%) as a white solid: mp108-109 (lit.3 mp 110C); IR numax 3315, 1687; 1HNMR d 1.39 (3 H, t, J = 7.1 Hz, OCH2CH3), 2.35 (6 H, s, NMe2),2.76 (2 H, t, J = 5.8 Hz, Me2NCH2CH2), 4.10 (2 H, t, J = 5.8 Hz, Me2NCH2CH2),4.39 (2 H, q, J = 7.1 Hz, OCH2CH3),6.99 (1 H, dd, J = 8.9, 2.4 Hz, 6-H),7.07 (1 H, d, J = 2.4 Hz, 4-H), 7.12(1 H, dd, J = 2.1, 0.8 Hz, 3-H), 7.28(1 H, d, J = 8.9 Hz, 7-H), 9.30 (1 H,s, NH); 13C NMR d14.32 (OCH2CH3),45.83 (NMe2), 58.38 (Me2NCH2CH2), 60.82 (OCH2CH3), 66.57 (Me2NCH2CH2), 103.67 (4-C), 108.13(3-C), 112.69 (7-C), 117.37 (6-C), 127.74 (2-C), 127.89 (3a-C), 132.42 (7a-C),153.83 (5-C), 162.01 (C=O)
According to the analysis of related databases, 4584-46-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Twum, Elvis A.; Nathubhai, Amit; Wood, Pauline J.; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3481 – 3489;,
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