In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27139-97-5 as follows. Computed Properties of C7H6BrCl
A 12 mL vial equipped with a magnetic stir bar was charged with 2-bromo-4-chloro methylbenzene (357.3 mg, 1.74 mmol). To this vial was added phenyl boronic acid (233 mg, 1.91 mmol), Pd(OAc)2 (19.5 mg, 0.09 mmol), P(Ph)3 (91.2 mg, 0.35 mmol), and K2 C03 (480 mg, 3.58 mmol). The vial was flushed with nitrogen and evacuated 3 times. A 10:1 mixture of anhydrous THF:H20 was then added by syringe. The resulting mixture was heated at 80 °C for 18 hours. The reaction was then cooled to rt whereupon 5 mL HzO was added. The reaction was extracted with EtOAc (3 x 10 mL) and the combined organic layers were dried over Na2 S04, filtered and concentrated under reduced pressure to yield an oil. The oil was purified using a 12 g ISCO Si02 column eluting with pure hexanes over a 30 minute period. The desired fractions were combinedand concentrated under reduced pressure to yield 5-chloro-2-methyl-1,1′-biphenyl as a clear oil(332 mg, 94percent yield). 1H NMR (400 MHz, Chloroform-d) 8 7.37-7.30 (m, 2H), 7.30-7.24 (m,1H), 7.23-7.18 (m, 2H), 7.16-7.09 (m, 3H), 2.14 (s, 3H).
According to the analysis of related databases, 27139-97-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABIDE THERAPEUTICS, INC.; JONES, Todd, K.; CISAR, Justin, S.; GRICE, Cheryl, A.; WANG, Dong-Hui; WEBER, Olivia, D.; WO2015/3002; (2015); A1;,
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