Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
Taking cytisine as a reactant,Using triethylamine as a catalyst,In a mixture of organic solvent benzene and acetonitrileSulfonylation of 2,4-dimethoxybenzenesulfonyl chloride,Among them, cytisine,The molar ratio of 2,4-dimethoxybenzenesulfonyl chloride to the catalyst is 15:20:20,The organic solvent is added in an amount of 100 times the number of moles of cytisine.The cytisine derivative can be obtained;After the sulfonylation reaction,After distillation under reduced pressure, a crude cytisine derivative is obtained.Then the crude cytisine derivative is used in a volume ratio of 30:11:1.The chloroform and methanol elution system can be separated by silica gel column chromatography to obtain high purity.N-2,4-dimethoxybenzenesulfonyl-cytisine.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangxi Tianyuan Biochemical Co., Ltd.; Li Weiguo; Liu Yingqian; Yang Chengjie; Ling Chunhua; Li Juncai; Chen Cheng; Zhang Junxiang; (29 pag.)CN108503640; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics