Synthetic Route of 1996-30-1, A common heterocyclic compound, 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, molecular formula is C6H3BrClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-bromo-4-chloro-1-fluorobenzene (2.5 mL, 20.52 mmol) and sodiumthiomethoxide (1.453 g, 20.72 mmol) in DMF (20 mL) was stirred at 100 C for 2 h. Thereaction mixture was added to water (20 mL) with stirring, and the aqueous mixture was extracted with ethyl acetate (3 x 50 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo to afford a oily residue that was purified by colunm chromatography on silica gel (hexanes/EtOAc: 20/1) to afford compound I-77a as a colorless oil.?H NMR (600 MHz, DMSO): oe 7.74 (d, J = 8.6, 2.3 Hz, 1 H), 7.49 (dd, J = 8.6, 2.3 Hz, 1 H),7.28 (d, J= 8.6 Hz, 1 H), 2.51 (m, 3 H).
The synthetic route of 1996-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHILDERS, Matthew L.; DINSMORE, Christopher; FULLER, Peter H.; GUERIN, David J.; KATZ, Jason David; PU, Qinglin; SCOTT, Mark E.; THOMPSON, Christopher F.; ZHANG, Hongjun; CAI, Jiaqiang; DU, Xiaoxing; WANG, Chonggang; KONG, Norman; LIU, Yumei; WO2014/146246; (2014); A1;,
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