In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-86-6, name is (2-Chloroethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9ClO
Example 1233-{[(frans-4-Methylcyclohexyl)carbonyl][2-(phenyloxy)ethyl]amino}-1-(4-pyrazolo[1,5- a]pyrimidin-2-ylphenyl)-1H-pyrazole-4-carboxylic acidTo Intermediate 119 (200 mg) was added anhydrous DMF (8 mL), and the resulting suspension was stirred at room temperature, under nitrogen for 5 minutes. Sodium hydride (60% dispersion in mineral oil) (34 mg) was then added, and the reaction mixture stirred at room temperature, under nitrogen for 25 minutes. Beta-chlorophenetole (331 mg) was added, and the reaction was stirred at 5O0C, under nitrogen for 20 h. Water (2 mL) was added to quench the reaction, and the mixture was stirred for 15 minutes before the solvent was removed by evaporation. The residue was then suspended in THF (2 mL) and ethanol (2 mL), and 2M lithium hydroxide solution (2 mL) was then added. The reaction mixture was stirred at room temperature for 24 h, and then neutralised using 2M HCI, and partitioned between water and DCM. The layers were stirred for 30 minutes, and then separated using a hydrophobic frit. The organic phase was then concentrated by evaporation, and purified using ISCO Companion C18 chromatography eluting with a gradient of acetonitrile (containing 0.05% formic acid) in water ( containing 0.1% formic acid) to give the title compound. MS calcd for (C32H32N6O4+H)+: 565 MS found (electrospray): (M+H)+= 565
The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/39146; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics