Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 454-78-4, name is 2-Bromo-1-chloro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks
Examples 1 :1 – 1 :8 (Procedure A).A mixture of VII (0.32 mmol), the appropriate aryl bromide (0.38 mmol), CS2CO3, (146 mg, 0.448 mmol), BINAP (15 mg, 0.024 mmol), Pd(OAc)2 (3.6 mg, 0.016 mmol) and toluene (3 mL) was stirred at 100 0C for 7 h and at rt for 14 h. The mixture was filtered through Celite and the solids washed with EtOAc. Concentration of the combined filtrates gave ester VIII in yields given in Tabe 1.
According to the analysis of related databases, 454-78-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOLIPOX AB; WO2009/127822; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics