Adding a certain compound to certain chemical reactions, such as: 621-62-5, name is 2-Chloro-1,1-diethoxyethane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-62-5, Application In Synthesis of 2-Chloro-1,1-diethoxyethane
A solution of 4-bromo-6-chloropyridazin-3-amine (15.7 g, 75.3 mmol), 2-chloro- 1,1- diethoxyethane (13.9 g, 90.3 mmol) and PTSA (17.2 g, 90.3 mmol) in isopropanol (150 mL) was heated to 80C for 20 h. After cooling to room temperature, the solution was concentrated in vacuo. The resulting mixture was treated with a saturated NaHC03 solution (300 mL), extracted with dichloromethane (200 mL x 3), dried over Na2S04, filtered and concentrated. The residue was purified by chromatography (silica gel, 200 – 300 mesh, petroleum ether : ethyl acetate = 3 : 1) to give 8-bromo-6-chloroimidazo[l,2-b]pyridazine (17.2 g, 98 %) as an orange solid. LC-MS: [M+H]+, 231.9, 233.9, tR = 1.46min
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu; WO2013/64445; (2013); A1;,
Chloride – Wikipedia,
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