Electric Literature of 121-27-7, These common heterocyclic compound, 121-27-7, name is 5-Chloro-2-(4-chlorophenoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 43.6 g. of isonicotinic acid, 200 ml. of thionyl chloride and 200 ml. of methylene chloride is heated under reflux for 2 hours. The solvent is evaporated, 93.4 g. of 5-chloro-2-(p-chlorophenoxy)aniline, 180.0 g. of anhydrous potassium carbonate and 2800 ml. of benzene are added and the reaction proceeds as described in Example 1. Extraction with petroleum ether gives 5′-chloro-2′-(p-chlorophenoxy)-isonicotinanilide.
The synthetic route of 121-27-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Cyanamid Company; US4221714; (1980); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics