Synthetic Route of 3260-88-6, These common heterocyclic compound, 3260-88-6, name is 2-Methyl-3-chloroanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 mL round bottom flask, l-chloro-3-methoxy-2-methylbenzene (5.0 g, 31.9 mmol) was dissolved in CCLt (5OmL). To the solution, l-bromopyrrolidine-2,5-dione (5.8 g, 32.6 mmol) and benzoyl benzenecarboperoxoate (70 mg) were added in sequence. The resulting mixture was refluxed for 4 hours and left at room temperature overnight. The mixture was filtered. The filtrate was evaporated to provide crude product of 2-(bromomethyl)-l-chloro-3-methoxybenzene as a colorless liquid, which was used for next step without further purification.
Statistics shows that 2-Methyl-3-chloroanisole is playing an increasingly important role. we look forward to future research findings about 3260-88-6.
Reference:
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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