Application of 4584-46-7, These common heterocyclic compound, 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 mL three-necked flask, 20 g of 2-dimethylaminochloroethane hydrochloride (139 mmol) was added,150 mL of DMF-H2O mixed solution (v/v: 7:3),10 grams of sodium azide (154 mmol) and a catalytic amount of NaI.The reaction solution was heated to 80 C., incubated for 36 h, and cooled to room temperature.The reaction solution was neutralized with sodium carbonate, and then the pH of the reaction solution was adjusted to 11 with sodium hydroxide.Add 100 mL of ethyl acetate and extract three times with 180 mL of ethyl ether to combine the organic phase.Dry over anhydrous magnesium sulfate, filter, and evaporate the solvent ether under reduced pressure at room temperature.Add 100g to the above residual ethyl acetate solution1-Iodine-1H,1H,2H,2H-perfluorodecane (174 mmol), warmed to 75C, and reacted overnight to precipitate a yellow solid, the supernatant was removed, and the solid was washed three times with ethyl acetate in a vacuum. After drying for 2 days, a fluoromonomer modified by a click functional group was obtained.
The synthetic route of 4584-46-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Keerbo New Materials Technology Co., Ltd.; Hu Jianqing; Peng Kaimei; Deng Jian; Guo Hongwei; (17 pag.)CN107573250; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics