Simple exploration of 2,4-Dichloro-6-(trifluoromethyl)aniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-6-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62593-17-3, COA of Formula: C7H4Cl2F3N

A.2.10.1 Synthesis of 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester To a suspension of CuCI2 (3.0 mmol) in 30 mL CH3CN was added tBu-nitrite (4.1 mmol) followed by dropwise addition of 1 ,1 -dichloroethylen (39.1 mmol). A solution of 2,4- dichloro-6-trifluoromethylaniline (2.2 mmol) in 2 mL CH3CN was slowly added. After stirring at RT overnight, the reaction was quenched with 25percent aqueous HCI solution and extracted 3 times with EtOAc. The combined organic layers were dried over MgS04. After removal of the solvent the crude was redissolved in 3 mL MeOH. After addition of 2.4 mL of a 30percent solution of NaOMe in MeOH the mixture was refluxed for 5 h. Then, 1.8 mL concentrated H2S04 solution was added at RT and the mixture was heated to reflux for 1 h. After concentrating in vacuo the resulting solid was partitionned between water and DCM. The water phase was extracted 3 times with DCM. The combined organic layers were dried over MgS04. Purification with CC using Hept/EtOAc (10/1 ) gives the desired product as yellowish oil. LC-MS (A): tR = 0.93 min; 1H NMR ((CD3)2SO) delta: 8.1 1 (s, 1 H), 7.88 (s, 1 H), 3.97 (s, 2H), 3.65 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-6-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; RENNEBERG, Dorte; STAMM, Simon; WO2013/108227; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics