Adding a certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9, Quality Control of 1-Bromo-4-chlorobutane
In a round bottom flask, 5.0 g of 7-hydroxyquinolin-2(1H)-one, 6.42 g K2CO3 and 25 ml acetone were taken and stirred for 30 minutes at 25-35 C. 5.89 g 1-bromo-4-chloro butane was added into the reaction mixture and stirred for 5-6 hours at 50-55 C. After completion of the reaction, the reaction mixture was cooled to 25-35 C. The reaction mixture was filtered. The solvent was removed by distillation under vacuum. The solid was dried in a hot air oven at 45-50 C. to obtain 7-(4-chlorobutoxy) quinolin-2(1H)-one. Yield: 85%.
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Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Sanjay Jagdish; PARIHAR, Jayprakash Ajitsingh; SHAH, Alpesh Pravinchandra; (21 pag.)US2017/320862; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics