Adding a certain compound to certain chemical reactions, such as: 89794-02-5, name is 4-Bromo-2-chlorotoluene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89794-02-5, Recommanded Product: 4-Bromo-2-chlorotoluene
Example 3 bis(3-chloro-4-methylphenyl)borate After ignition drying of magnesium piece (0.97g) in vacuo and purging with argon, anhydrous THF (40ml) and 1,2-dibromoethane (a few drops) were added.. Solution of 3-chloro-4-methylphenyl bromide (6.2g) in THF (20ml) was delivered by drops to the mixture over one hour at room temperature and the reaction mixture was heated to reflux for 30 minutes.. The reaction mixture was cooled to room temperature and added slowly to solution of trimethyl borate (1.36ml) in THF (20ml) cooled to -78C and the mixture was left standing to be warmed to room temperature. 1N hydrochloric acid (100ml) was added to the reaction mixture and the water layer was extracted with ethyl acetate.. The organic layer was dried with anhydrous sodium sulfate and concentrated.. The residue was purified by column chromatography (ethyl acetate: hexane = 1: 1), and the obtained solid was recrystallized to obtain the title compound (2.89g) having the following physical data. TLC: Rf 0.38 (ethyl acetate: hexane = 1:1); NMR (200 MHz, CDCl3): delta 7.72 (2H, s), 7.53 (2H, d, J = 7 Hz), 7.29 (2H, d, J = 7 Hz), 5.7-6.0 (1H, br), 2.45 (6H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chlorotoluene, and friends who are interested can also refer to it.
Reference:
Patent; Mikoshiba, Katsuhiko; EP1444981; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics