Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 694-80-4, Name is 1-Bromo-2-chlorobenzene, molecular formula is C6H4BrCl. In an article, author is Sundaram, M. Nivedhitha,once mentioned of 694-80-4, Category: chlorides-buliding-blocks.
Vasoconstrictor and coagulation activator entrapped chitosan based composite hydrogel for rapid bleeding control
Chitosan (Cs) as a hemostatic agent has been in use to control hemorrage. Composite hydrogel formed by entrapment of vasoconstrictor-potassium aluminium sulfate (0.25 %PA) and coagulation activator-calcium chloride (0.25 %Ca) into Cs (2 %) hydrogel would enhance the hemostatic property of Cs. In this work, the prepared composite hydrogel was injectable, shear thinning, cyto and hemocompatible. The 2 %Cs-0.25 %PA0.25 %Ca composite hydrogel caused rapid blood clotting by accelerating RBC/platelet aggregation and activation of the coagulation cascade. Further, in vivo studies on rat liver and femoral artery hemorrage model showed the efficiency of 2 %Cs-0.25 %PA-0.25 %Ca composite hydrogel to achieve hemostasis in a shorter time (20 +/- 10 s, 105 +/- 31 s) than commercial hemostatic agents-Fibrin sealant (77 +/- 26 s, 204 +/- 58 s) and Floseal (76 +/- 15 s, 218 +/- 46 s). In in vivo toxicological study, composite hydrogel showed material retention even after 8 weeks post-surgery, therefore excess hydrogel should be irrigated from site of application. This prepared composite hydrogel based hemostatic agent has potential application in low pressure bleeding sites.
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