Application of 89794-02-5,Some common heterocyclic compound, 89794-02-5, name is 4-Bromo-2-chlorotoluene, molecular formula is C7H6BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of aryl bromide (3 equiv), Mg (3 equiv), and DIPAB or DICAB (1 equiv) in dry THF (1 mL/mmol) was added at r.t. a solution of 2 M PhMgBr in THF (0.05 equiv). After 10 min (or at the end of gas evolution on large scale), the mixture was heated to 70 C until no aryl bromide remained in the mixture (8-16 h). At 0 C, dry MeOH (1mL/mmol) was added (caution, exothermic reaction). After 1 h, the mixture was concentrated under reduced pressure, and diluted in a mixture of 1 M HCl/MeOH (7:3, 10 mL/mmol), after 1 h, the product was extracted with Et2O (3 ¡Á 10 mL/mmol) and the combined organic phases were washed with 1 M HCl (10 mL/mmol) and brine (3 ¡Á 10mL/mmol). Organic phases were then dried (anhyd Na2SO4), and concentrated under reduced pressure. The residue was dissolved in Et2O (4 mL/mmol) and ethanolamine (1.2 equiv) was added. Depending on the substituents, precipitation occurs spontaneously or requires the addition of pentane. Crystals were filtered, washed with pentane and dried under vacuum to yield the pure 2-aminoethyl borinate.
The synthetic route of 89794-02-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Richard, Jimmy; Birepinte, Melodie; Charbonnier, Jean Baptiste; Liautard, Virginie; Pinet, Sandra; Pucheault, Mathieu; Synthesis; vol. 49; 4; (2017); p. 736 – 744;,
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