In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Bromo-3,5-dichlorobenzene
(l-Benzyl-lH-[l,2,4]triazol-3-yl)-(3,5-dichloro-phenyl)-amine (Compound 23) A mixture ofl-benzyl-lH-l,2,4-triazol-5-amine 2,2,2-trifluoroacetate (mixture of isomers) (292 mg, 1.01 mmol, Eq: 1.24),l-bromo-3,5-dichlorobenzene (185 mg, 819 muiotaetaomicron, Eq: 1.00), sodium tert-butoxide (341 mg, 3.55 mmol, Eq: 4.33), tris(dibenzylideneacetone)dipalladium(0) (18.7 mg, 20.5 muiotaetaomicron, eq: 0.025) and 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (34.8 mg, 81.9 muiotaetaomicron, Eq: 0.10) in a 2-5 mL microwave vessel. Sealed the vessel. Evacuated the system and recharged with nitrogen (2x). Added toluene and heated in an oil bath at 110¡ãC overnight. The reaction mixture was diluted with EtOAc, washed with water and brine. Dried (Na2S04) and concentrated over celite. The crude material was purified by flash chromatography (silica gel, SF40-80 g, 25percent to 50percent EtOAc in hexanes) to give 2 major products. The more polar fraction was desired product 116 mg, which was triturated with methanol, filtered and rinsed with ether to give 42 mg (16percent) of desired product as a white solid. The less polar fraction was determined to be isomeric product, (2-Benzyl-2H-[l,2,4]triazol-3-yl)-(3,5-dichloro-phenyl)- amine. MS m/z 319 [M+H]
The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
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