Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 452-66-4, name is 4-Chloro-1-fluoro-2-methylbenzene, A new synthetic method of this compound is introduced below., Formula: C7H6ClF
EXAMPLE 9 N-[(5-Chloro-2-fluorophenyl)methyl]-N-methyl-3-hydroxy-3-phenylpropylamine A mixture of 5-chloro-2-fluorotoluene (2.9 g; prepared by a modified Schiemann reaction on 4-chloro-2-methylaniline), NBS (3.6 g) benzoyl peroxide (100 mg) and carbon tetrachloride (25 ml) was refluxed 2h. The mixture was cooled, filtered and the solvent removed. Distillation gave 5-chloro-2-fluorobenzyl bromide (3 g), b.p. 104/15 mm.
The synthetic route of 452-66-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; John Wyeth & Brother Limited; US4318909; (1982); A;,
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