Application of 13726-14-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13726-14-2 name is 4-Chloro-3-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Concentrated hydrochloric acid (12 mL) and a solution of sodium nitrite (1.7 g, 24.4 mmol) in water (8 mL) were added to a solution of 4-chloro-3-methoxy aniline (3.86 g, 24.4 mmol) in water (8 mL), at -10 C. The mixture was stirred for 30 minutes and was then added to solution of tin chloride (14.89 g, 66 mmol) in concentrated hydrochloric acid (24 mL) and water (24 mL), cooled to 0 C. The reaction mixture was stirred for 18 hours, allowing the temperature to rise to 25 C. The resulting precipitate was filtered off and the solid was re-crystallized from heptanes/ethyl acetate (33:66) to afford the title compound the title compound as white solid in 72% yield, 3 g
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-3-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; Mathias, John Paul; Millan, David Simon; Lewthwaite, Russell Andrew; Phillips, Christopher; US2006/35922; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics