Synthetic Route of 15205-15-9, These common heterocyclic compound, 15205-15-9, name is 2-Chloro-6-fluorobenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : Preparation of 4-[(2-chloro-6-fluorobenzyl)amino]-N-(3,4- dimethoxyphenyl)pyridine-3-sulfonamide A solution of 4-Chloro-N-(3,4-dimethoxyphenyl)pyridine-3-sulfonamide (IntDI) (0.5 g, 1.50 mmol), 2-chloro-6-fluoro-benzylamine (0.26 g, 1.67 mmol) and K2C03 (0.41 g, 3.0 mmol) in DMF (10 mL) was heated at 130C for 4 h. The mixture was added to saturated aqueous NaHC03 (50 mL), extracted with EtOAc (3 x 25mL) and the combined organic phases dried over Na2S04 and concentrated in vacuo. Purification by gradient column chromatography eluting with 0-45% EtOAc in hexane yielded the title compound (40 mg, 0.09 mmol). LCMS (Method B): (ESI +ve) 451.8. [M+H]+.
The synthetic route of 15205-15-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; CHRISTOPHER, John Andrew; TEHAN, Benjamin Gerald; KLAIR, Sukhbinder Singh; AVES, Sarah Joanne; WO2014/6402; (2014); A1;,
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