Reference of 10272-06-7, These common heterocyclic compound, 10272-06-7, name is 3-Chloro-5-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(5.0 g, 31.72 mmol) was added to a stirred solution of (2) (3.11 g,31.72 mmol) in Et20 (60 mL) at a The reaction mixture was stirred at rt for 4 hr. The resulting mixture was evaporated in vacuo to give the crude product. This was triturated with Et20 and dried in vacuo to give 5.0 g (61.7% yield) of pure product as an off-whitesolid, which was used without further purification in the next step. LCMS m/z 256 [M + H- 11, 25 [M + H + 11, 264 [M + H + 31; (99.4% purity). ?H NMR (400 MHz, DMSO-d6) oe12.89 (br s, 1H), 10.43 (s, 1H), 7.36 (dd, J = 2.0 Hz, J = 1.6 Hz, 1H), 7.16 (dd, J = 2.0 Hz, J = 2.0 Hz, 1H), 6.76 (dd, J = 2.4 Hz, J = 2.0 Hz, 1H), 6.44 (d, J = 12 Hz, 1H), 6.31 (d, J = 12 Hz, 1H), 3.75 (s, 3H).
The synthetic route of 10272-06-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FLATLEY DISCOVERY LAB, LLC; ZAWISTOSKI, Michael, P.; DESHPANDE, Asmita; COLE, Bridget, M.; (149 pag.)WO2017/117239; (2017); A1;,
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