Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: (2-Chloroethoxy)benzene
2-(4-Chlorophenyl)butanoic acid (397.3 mg, 2.0mmol) was suspended with stirring in trifluoroacetic anhydride (277.4 uL, 2.0mmol). Then (2-chloroethoxy)benzene (252.4 uL, 1.8 mmol) was added dropwise andthe resulting mixture was stirred at room temperature overnight. The reactionwas quenched with saturated sodium bicarbonate solution (5 mL) and extractedwith ethyl acetate (2 x 15 mL). Thecombined organic layers were dried over anhydrous magnesium sulfate andconcentrated on a rotary evaporator. Theresulting residue was purified by reverse-phased chromatography (C-10 column,gradient of acetonitrile in water with 0.1% trifluoroacetic acid) to afford297.1 mg (49%) of the desired product as a yellow solid. 1H NMR (400 MHz, MeOD) delta 7.99 (d,J = 8.9 Hz, 2H), 7.28 (m, 4H), 6.96 (d, J = 8.9 Hz, 2H), 4.58 (t, J = 7.2Hz,1H), 4.27 (t, J = 5.5 Hz, 2H), 3.84 (t, J = 5.5 Hz, 2H), 2.11 (m, 1H), 1.78(m, 1H), 0.88 (t, J = 7.3 Hz 3H); MS (ESI) (m/z) 318.1/320.1 (M+H)+.
The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
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