Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 821-10-3, name is 1,4-Dichlorobut-2-yne, A new synthetic method of this compound is introduced below., Product Details of 821-10-3
To a solution of compound 15G (1.0 g, 1.9 mmol, 1.0 eq) in DMF (15 mL) was added 1 ,4-dichlorobut-2-yne (490 mg, 4.0 mmol, 2.0 eq), K2C03 (800 mg, 5.8 mmol, 3.0 eq) and Nal (290 mg, 1.9 mmol, 1.0 eq). The mixture was stirred at 80 C for 3 hours before it was concentrated under reduced pressure. The residue was purified by column chromatography (hexanes/EtOAc =10/1 to 5/1 ) to give compound 62A (900 mg, 77%).ESI-MS: [M+H]+: 603
The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; HECKER, Scott; REDDY, Raja, K.; (198 pag.)WO2016/149393; (2016); A1;,
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