Synthetic Route of 452-73-3, A common heterocyclic compound, 452-73-3, name is 2-Chloro-4-fluoro-1-methylbenzene, molecular formula is C7H6ClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A Synthesis of 2-chloro-4-fluorobenzal bromide In a flask were placed 150 g (1.04 moles) of 2-chloro-4-fluorotoluene, 391 g (2.20 moles) of N-bromosuccinimide, 3 g (0.012 mole) of benzoyl peroxide, and 800 ml of carbon tetrachloride. This mixture was refluxed overnight and then filtered. The solvent was evaporated under reduced pressure, leaving a residue of impure 2-chloro-4-fluorobenzal bromide weighing 340 g.
The synthetic route of 452-73-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FMC Corporation; US4846875; (1989); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics