Electric Literature of 202925-07-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202925-07-3, name is 2-Chloro-1-fluoro-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
2- Chloro-3-fluoro-6-methoxybenzaldehydeTo a solution of 2-chloro-1 -fluoro-4-methoxybenzene (28.5 g, 178 mmol) in i-butyl methyl ether (200 mL, dried over anhydrous MgS04) at -78 C was added 2.5 M n-butyl lithium in hexanes (107 mL, 268 mmol). After 3 h, methyl formate (18.76 mL) was added dropwise while keeping the temperature below -60 C. The reaction mixture was quenched with sat. aq. ammonium chloride (250 mL) after 45 minutes and the organic layer was separated. The aq. layer was extracted with ethyl acetate (2×100 mL), and the combined organic layers were washed with water (200 mL) followed by brine, dried (Na2S04) and concentrated to give a residue which on trituration with hexanes gave solids. The solids were filtered, taken again in hexanes and heated over a steam bath. The mixture was cooled, and the light yellow desired product filtered off and air-dried to give the title compound. 1H NMR (400 MHz, CDCI3): delta = 10.48 (d, J = 0.8 Hz, 1 H), 7.31 (dd, J = 9.4, 7.8 Hz, 1 H), 6.88 (dd, J = 7.8, 3.8 Hz, 1 H), 3.92 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-1-fluoro-4-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; OSI PHARMACEUTICALS, LLC; LI, An-Hu; MULVIHILL, Mark, J.; STEINIG, Arno, G.; WO2011/143646; (2011); A1;,
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