Reference of 1205-71-6, These common heterocyclic compound, 1205-71-6, name is 4-Chloro-N-phenylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 ml round bottom flask, 8-bromobenzo [b] naphtho [2,1-d] thiophene (12 mmol), copper iodide (15 mmol), potassium tert-butoxide (65 mmol), 1,2-di Aminocyclohexane (12 mmol) and (12 mmol) (3-chloro-phenyl) -phenylamine were added to dry 1,4-dioxane (100 ml), and the mixture was refluxed under N2 atmosphere for 48 hours. The intermediate was cooled to room temperature, added to water, and then filtered through a pad of celite while extracting with dichloromethane, then washed with water, and dried over anhydrous magnesium sulfate. After filtration and evaporation, the crude product was purified by silica gel column chromatography to obtain Intermediate HT042-1.
Statistics shows that 4-Chloro-N-phenylaniline is playing an increasingly important role. we look forward to future research findings about 1205-71-6.
Reference:
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Zhang Lei; Gao Wei; Niu Jinghua; Dai Wenpeng; Xiao Wenjing; Lu Yan; Zhu Hongyan; (28 pag.)CN110746391; (2020); A;,
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