Related Products of 461432-23-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Take 32 kg of 5-bromo-2-chloro-4′-ethoxydiphenylmethane, add 100 kg (1:4) of anhydrous THF/toluene to the 500 liter reactor under nitrogen, and cool the liquid nitrogen to – 78 C,34 L of a 1.6 mol¡¤L-1 n-butyllithium hexane solution was slowly added dropwise, and the mixture was stirred at this temperature for 1 h. Will be cold to -78 C2,3,4,6-tetra-O-trimethylsilyl-D-gluconolactone100 kg of a toluene solution (26 kg) was slowly added dropwise to the above reaction liquid, and reacted at -78 C for 3 hours. After the completion of the reaction, 50 kg of a methanol solution of methanesulfonic acid (23 kg of methanesulfonic acid + 27 kg of methanol) was added thereto. The reaction was stirred at 0 C for 4 h, then warmed to 40 C and stirred for 7 h. A 5 mol¡¤L-1 aqueous sodium hydroxide solution was added to the reaction solution to adjust the pH to 7-8. After stirring for 30 min, it was extracted with ethyl acetate (50 kg¡Á2). The organic phase was washed with saturated aqueous sodium chloride to neutral, then dried over anhydrous sodium sulfateA yellowish viscous oil was obtained in an amount of 34.6 kg, yield 78%.
The synthetic route of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Southeast University; Chen Junqing; Zhang Xiaolu; (9 pag.)CN108084130; (2019); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics