In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6940-78-9 as follows. COA of Formula: C4H8BrCl
Example 8; Preparation 7-CBQ by a reaction of 7-HQ with 1-bromo-4-chlorobutane in 2-propanol in Presence of potassium carbonate; A mixture of 7-hydroxy-3,4-dihydro-2(1H)-quinolinone (10 g, 0.061 mole), 1-bromo-4-chlorobutane (21.5 ml, 31.88 g, 0.183 mole, 3 eq.) and potassium carbonate (9.25 g, 0.067 mole, 1.1 eq.) in 2-propanol (50 ml) was heated under reflux for 12 hours. The hot reaction mixture was filtered, and the solvent and excess 1-bromo-4-chlorobutane were removed to dryness in vacuum. 2-Propanol (32 ml) was added to the residue thus obtained and the mixture was heated under reflux to obtain a solution. A solution of 47% aqueous sodium hydroxide was added to the hot solution to produce pH of about 10-11 and the mixture was set aside at 10-15 C. for 6 hours. A colorless precipitate was collected by filtration, washed with the cold mixture of water and 2-propanol (1:3, 15 ml) and water (25 ml) and dried under reduced pressure at 50 C. overnight to obtain 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone (14.4 g) in 92.6% yield, having a purity of 98.4% (by HPLC).
According to the analysis of related databases, 6940-78-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Naddaka, Vladimir; Brand, Michael; Davidi, Guy; Klopfer, Eyal; Gribun, Irina; Arad, Oded; Kaspi, Joseph; US2006/79689; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics