Related Products of 7781-10-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7781-10-4, name is 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To 1.9 g (9.2 mmol) of methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate in 50 cm3 ofdimethylsulfoxyde under argon atmosphere, were added 1.85 g (11.0 mmol) of 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine , followed by 3.2 g (23.0 mmol) ofpotassium carbonate. The reaction mixture was heated at about 120C for 24 hours,upon which it was cooled to about 20C and treated with 200 cm3 of distilled water.The mixture was then treated with 300 cm3 and 150 cm3 of ethyl acetate and filteredon Celite. The aqueous phase was extracted with 150 cm3 of ethyl acetate. Thecombined organic extracts were dried on magnesium sulfate and concentrated todryness in vacuo (2.7 kPa). The residue was purified via column chromatography onsilica gel (0,04-0,06 mm), with dichloromethane/methanol 99:1 v/v as eluting solvent.Thus, 1.25 g of methyl 1-(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate were obtained as a light-yellow crystalline powder, mp: 207C
The synthetic route of 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AVENTIS PHARMA DEUTSCHLAND GMBH; WO2004/111048; (2004); A1;,
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