Related Products of 63624-28-2, A common heterocyclic compound, 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, molecular formula is C8H9ClO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 16a (26.30mg, 0.10mmol), acetyl chloride (7.80mg, 0.10mmol), and pyridine (2.0mL) was stirred at 60C and monitored by TLC. Pyridine was removed under reduced pressure. Then the mixture was basified by 1N NaOH aqueous solution (pH?9), extracted with CH2Cl2 (20mL¡Á3), washed with brine (5mL¡Á3), dried over anhydrous Na2SO4, and concentrated under reduced pressure. The obtained residue was purified by chromatography (petroleum ether/ethanol=8:1, v/v) to afford 2a (0.3g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Song, Pinrao; Chen, Ming; Ma, Xiaodong; Xu, Lei; Liu, Tao; Zhou, Yubo; Hu, Yongzhou; Bioorganic and Medicinal Chemistry; vol. 23; 8; (2015); p. 1858 – 1868;,
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