Related Products of 14862-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14862-52-3 as follows.
Nitrogen environment at biphenyl-4-ylboronic acid (100 g, 505 mmol) and tetrahydrofuran (THF) and then dissolved in 1.3 L, here 1,3-dibromo-5-chlorobenzene (150 g, 555 mmol) and tetrakis (triphenylphosphine) palladium (5.05 g, 5.84mmol) and the mixture was stirred. Into the potassuim carbonate (174 g, 1,263 mmol) in a saturated water it was heated to reflux at 80 for 7 hours. After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. Separating the thus obtained residue was refined and flashcolumnchromatography W to give the compound I-3 (149 g, 86%).
According to the analysis of related databases, 14862-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHEIL INDUSTRIES INC.; HAN ILL, LEE; SU JIN, HAN; YOUNG KWON, KIM; EUN SUN, YU; HO KUK, JUNG; (66 pag.)KR2015/117173; (2015); A;,
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