Synthetic Route of 918538-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of Compound 4.1. Into a 50-mL round-bottom flask, was placed 2,4- dichloropyrrolo[2, l- J[l,2,4]triazine (200 mg, 1.06 mmol, 1.00 equiv), sodium carbonate (227 mg, 2.14 mmol, 2.00 equiv), (r,4r)-Nl, ^-dimethyl cyclohexane-l,4-diamine (276 mg, 1.94 mmol, 1.20 equiv) in ACN (20 mL). The reaction was stirred overnight at 80 C in an oil bath. Then it was concentrated in vacuo and the residue was purified by silica gel column chromatography with dichloromethane/methanol (20: 1). This resulted in 180 mg (58%) of 4.1 as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; (102 pag.)WO2017/4134; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics