These common heterocyclic compound, 367-22-6, name is 4-Chloro-3-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Chloro-3-fluoroaniline
To a solution of 1005 (10.0 g, 68.7 mrnol) in heptane (100 ml) was added(Boc)20 (16.4 rnL, 76.6 rnmol) After stirring the reaction mixture at 80C for 16 h, solvent wasevaporated and the residue was purified by Comhiflash column chromatography (hexane/EtOAc, 1:2) to afford 1006 (7.0 g, 43%) as a solid. 1H NMR (400 MHz, CDC13): oe 7.44 (dd, 1H), 727 (t, IH), 694 (dd, 1H), 6.53 (s, 1H). 1.50 (s, 9H).
The synthetic route of 4-Chloro-3-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017/48612; (2017); A1;,
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