Related Products of 694-80-4, A common heterocyclic compound, 694-80-4, name is 1-Bromo-2-chlorobenzene, molecular formula is C6H4BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 10; 2-(2-Chlorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-oneTo a solution of 6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-one (1.50 g, 8.5 mmol, obtained in reference example 9) in N-methylpyrrolidone (4 mL) under argon, 1-bromo-2-chlorobenzene (2.34 g, 12.3 mmol), copper (I) iodide (0.33 g, 1.7 mmol) and potassium carbonate (2.33 g, 16.9 mmol) were added and the mixture was heated at 200 C. overnight. It was allowed to cool and CHCl3 and 1N NaOH were added. The phases were separated and the aqueous phase was reextracted 2 times with CHCl3. The combined organic phases were dried over Na2SO4 and the solvent was evaporated. The crude product thus obtained was purified by chromatography on silica gel using hexane-EtOAc mixtures of increasing polarity as eluent, to afford 2.01 g of the desired compound (yield: 77%).LC-MS (method 1): tR=8.05 min; m/z=288.1/290.1 [M+H]+.
The synthetic route of 694-80-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PALAU PHARMA, S.A.; US2010/222363; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics