Reference of 367-21-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 367-21-5 as follows.
(1) 145.6 g (1.00 mol) of 3-chloro-4-fluoroaniline were dissolved in a mixture of 330 ml of 48% strength hydrobromic acid and 330 ml of water and diazotized by adding a solution of 70.4 g (1.02 mol) of sodium nitrite in 220 ml of water dropwise at 5 C. The diazonium salt solution thus obtained was added dropwise to a mixture of 188 g (1.3 mol) of copper(I) bromide and 400 ml of 48% strength hydrobromic acid at 30-40 C. After conclusion of gas evolution, the produce was extracted using three 300 ml portions of hexane. The extracts were washed twice with 5N sodium hydroxide solution and once with water, dried over sodium sulfate and evaporated. The residue yielded 187.2 g (89%) of 4-bromo-2-chlorofluorobenzene of b.p.10 =73-75 C. with a purity >99% (determined by gas chromatography) on subsequent distillation.
According to the analysis of related databases, 367-21-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hoechst Aktiengesellschaft; US4920212; (1990); A;,
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