Synthetic Route of 626-43-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-43-7, name is 3,5-Dichloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To the 250 mL reaction flask was added solid phosgene (13.8 g, 0.046 mol) (purchased from Zhejiang Lishui Yibang Chemical Co., Ltd., purity 99%, the same hereinafter) and toluene (60 g), and 3,5-dichloroaniline (16.2 g, 0.1 mol) (Purity: 99%, the same as below) with triethylamine (1.0 g, 0.01 mol) (purchased from Beijing Chemical Reagent Co., Ltd., purity: 99%, same as below) and toluene (40.0 g) was added dropwise at a temperature of 48 ¡À 2 C for about 45 min.The temperature was raised to 75 C and incubated for 4 hours. and then continue to heat up to 110 C and heat 3 hours, the sample monitoring to 3,5-dichloroaniline content of less than 0.5%, cooling to 60 C, and the introduction of nitrogen to eliminate excess phosgene and hydrochloric acid gas reaction. To give toluene solution A1 (114.5 g, w / w = 15.7%) of 3,5-dichlorophenyl isocyanate in a yield of 95.6%.
The synthetic route of 3,5-Dichloroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Yingtai Jiahe Biotechnologies Co Ltd; Wang, Wenjun; Jin, Wentao; Yu, Huimei; Ma, Jinyong; Yang, Dazhi; (12 pag.)CN103539744; (2016); B;,
Chloride – Wikipedia,
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