Adding a certain compound to certain chemical reactions, such as: 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1996-30-1, Application In Synthesis of 3-Bromo-4-fluorochlorobenzene
Step 1: [4-({(l/?,3/?,45)-3-({[ieri-Butyl(dimethyl)silyl]oxy}methyl)-4- [(triisopropylsilyl)oxy]cyclopentyl}amino)pyrimidin-5-yl]{5-chloro-4-[(S)-(5-chloro-2- fluorophenyl)(hydroxy)methyl]-2-thienyl}methanone and Butyl(dimethyl)silyl]oxy}methyl)-4-[(triisopropylsilyl)oxy]cyclopentyl}amino)pyrimidin-5-yl]{5- chloro-4-[(J?)-(5-chloro-2-fluorophenyl)(hydroxy)methyl]-2-thienyl}methanone. [00786] To a solution of 3-bromo- l -chloro-4-fluorobenzene (69.0 uL, 0.57 mmol) in THF (5.00 mL) at 0 C was added dropwise 2 M isopropylmagnesium chloride in Et20 (0.31 mL, 0.62 mmol) and the mixture was stirred at 0 C for 1 hour, and then warmed to rt overnight. This mixture was added dropwise to a solution of lnt-270 ( 185 mg, 0.28 mmol) in THF (8.0 mL) at -40 C and the reaction was allowed to stir at for 30 min at same temperature. The reaction was quenched by addition of saturated NH4C1 and extracted with EtOAc (x2). The combined organic layers were washed with brine, dried over MgS04, and concentrated in vacuo. The residue was purified by ISCO column chromatography (20% EtOAc in hexanes as eluent) to give 0.14g (63%) of the title compounds. LCMS (FA): m/z =782.2 (M+H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-4-fluorochlorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DUFFEY, Matthew O.; ENGLAND, Dylan; FREEZE, Scott; HU, Zhigen; LANGSTON, Steven, P.; MCINTYRE, Charles; MIZUTANI, Hirotake; ONO, Koji; XU, He; (684 pag.)WO2016/4136; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics