Related Products of 15205-11-5, These common heterocyclic compound, 15205-11-5, name is 2-Chloro-4-fluorobenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 120; 2-(3-butyl-5-methyl-1 -phenyl-1 H-pyrazol-4-yl)-lambda/-[(2-chloro-4- fluorophenyl)methyl]acetamide (E120)(3-Butyl-5-methyl-1 -phenyl-1 H-pyrazol-4-yl)acetic acid (0.100 g, 0.36 mmol, prepared as described below) was dissolved in dimethylformamide (5 ml) and treated with water soluble carbodiimide (0.138 g, 0.72 mmol), 1-hydroxybenzotriazole (0.099 g, 0.72 mmol), diisopropylethylamine (0.26 ml, 1.45 mmol), and [(2-chloro-4- fluorophenyl)methyl]amine (0.1 17 g, 0.72 mmol) and the mixture was stirred at room temperature for -48 hrs. The mixture was diluted with 2M aqueous hydrogen chloride and extracted with ethyl acetate. The combined organic layers were then washed with saturated aqueous sodium hydrogen carbonate, dried over anhydrous sodium sulphate, and evaporated to give the crude product. This was purified by mass-directed automated HPLC to give the title compound as product (0.087 g) after concentration of the combined product fractions and trituration with diethyl ether. LC/MS [M+H]+ = 414, retention time = 3.21 minutes.
Statistics shows that 2-Chloro-4-fluorobenzylamine is playing an increasingly important role. we look forward to future research findings about 15205-11-5.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/138876; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics