Related Products of 344-19-4, A common heterocyclic compound, 344-19-4, name is 2,6-Dichloro-4-fluoroaniline, molecular formula is C6H4Cl2FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The appropriate aromatic amine (1mmol) was dissolved under Ar in dry 47 CH2Cl2 (3mL), cooled in an ice bath and treated with a solution of 12 phenyl chloroformiate (190muL, 1.5mmol) and 48 pyridine (200muL, 2.5mmol) in dry CH2Cl2 (1mL). The mixture was then stirred for 2hat room temperature and then worked up. The residue was subjected to column chromatography on silica gel (elution with hexane-EtOAc 9:1) to afford the corresponding 13 urethane.
The synthetic route of 344-19-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Blasco, Victor; Cunat, Ana C.; Sanz-Cervera, Juan F.; Marco, J. Alberto; Falomir, Eva; Murga, Juan; Carda, Miguel; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 817 – 828;,
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