Reference of 60633-25-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60633-25-2, name is 2-Bromo-4-chloro-1-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of the product from preparation 7 (45 mg, 0.075 mmol) in ethanol (0.2 ml_) was added 2-bromo-4-chloro-1-methoxybenzene(11 mg, 0.05 mmol) in 1 ,4-dioxane (0.2 ml_) followed by Pd(PPh3)4 (10 mg) and 2M aq Na2CO3 (0.2 mL, 0.4 mmol). The mixture was stirred at 95C for 2 hours, after which the solvent was removed. The residue was partitioned between water (2ml) and ethyl acetate (twice at 2ml). The combined organic layers were washed with saturated NaCI (2ml), dried (magnesium sulfate) and concentrated. The residue was purified by HPLC to yield the title compound (9.7 mg). MS (ES+) CaIc: 623.11 , Found: 623.9 (M+1 ).
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-4-chloro-1-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2006/56854; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics