According to the analysis of related databases, 20850-43-5, the application of this compound in the production field has become more and more popular.
Application of 20850-43-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20850-43-5 as follows.
Preparation of 1, 3-benzodioxol-5-ylmetlyl ethyl sulfone 8.6 g of 5-(chloromethyl)-1, 3-benzodioxol was dissolved in 20 ml of anhydrous tetrahydrofuran and 20 ml of diethyl ether and then added to magnesium at 0C. The reaction was done for 10 minutes and then for 1 hour at 50C. The reaction mixture was cooled to 0C and then slowly added to the flask containing [1,3-bis (diphenylphosphino) propane] nickel (II) dichloride as a catalyst. After the addition of 3.7 ml ethane sulfonyl chloride, the mixture was reacted for 30 minutes. The reactant was then heated to 50C and reacted for 1 hour. Then, its pH was adjusted to 7 with dilute hydrochloric acid. The resulting mixture was extracted with diethyl ether and distilled water, dried over anhydrous magnesium sulfate and the solvent was removed. The residue was fractionated by column chromatography using ethyl acetate: n-hexane (1: 3), to give 0.3 g of the title compound of the following formula lb (Rf: 0.35, Yield: 3%). [Chemical Formula 1b] The compound was dissolved in CDC13 and TMS and then characterized by’H NMR spectroscopy. The result is as follows; ‘H NMR 5 : 1.57-1. 64 (t, 3H, J=7.3Hz), 2.78 (s, 2H), 3.60-3. 78 (q, 2H, J=7.3Hz), 5.90 (s, 2H), 6.56-6. 79 (m, 3H).
According to the analysis of related databases, 20850-43-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HAN, Sang Min; LEE, Myung Hee; CHOI, Won Chul; WO2005/70915; (2005); A1;,
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