In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 61881-19-4
General procedure: t-BuOK (40.3mg, 0.36mmol) were added to a solution of fluorinated imidoyl chlorides 1 (0.45mmol) and isocyanides 2 (0.3mmol) in DMF (2.0mL). The mixture was stirred at 60C under air for 1h. After the completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature, quenched by water and extracted with ethyl acetate (3¡Á15mL). The extract was dried over anhydrous Na2SO4 and the solvent was removed in vacuo to provide a crude product, which was purified by column chromatography on silica gel with petroleum ether/EtOAc as eluent to afford the imidazole products 3.
The synthetic route of 61881-19-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Zhengkai; Hu, Sipei; Wu, Xiao-Feng; Yang, Hefei; Tetrahedron; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics