Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 203302-92-5, name is 3-Bromo-2-chloro-6-fluorotoluene, A new synthetic method of this compound is introduced below., SDS of cas: 203302-92-5
N-bromosuccinimide (“NBS”) (6.42 g) and benzoyl peroxide (catalytic amount) in carbon tetrachloride (40 ml) was heated to reflux. A 500 watt tungsten halogen lamp was used to initiate the reaction. The reaction mixture was heated to reflux and irradiated for 30 minutes. The reaction mixture was allowed to cool to ambient temperature and then filtered. The filtrate was concentrated to give a colorless oil which solidified on standing to give l-bromo-3-bromomethyl-2-chloro-4-fluoro-benzene as an off-white solid (10.7 g). IH-NMR (400 MHz, CDCl3): 7.58 (dd, IH), 6.94 (t, IH), 4.64 (d, 2H) ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SYNGENTA LIMITED; WO2009/63180; (2009); A1;,
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