Application of 112-26-5, The chemical industry reduces the impact on the environment during synthesis 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, I believe this compound will play a more active role in future production and life.
NaI (46.2 mg, 0.308 mmol), 1,2-bis(2-chloroethoxy)ethane (48 muL, 0.308 mmol) and Cs2CO3 (100 mg, 0.308 mmol) were mixed in DMF (1.0 mL) at rt. The mixture was protected from light, and heated to 100 C for 15 min, after which time, 7-hydroxy-2H-chromen-2-one (50 mg, 0.308 mmol) was added. The reaction was heated for 75 min more, then cooled to rt. The mixture was quenched with 1 N HCl, and extracted with EtOAc (3 x 4 mL). The combined organic layers were evaporated to dryness. The crude material was purified by flash column chromatography (silica gel, solvent gradient 0-50% EtOAc in heptane) to give 32% yield of intermediate chloride SI-1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ross, Audrey G.; Benton, Bret M.; Chin, Donovan; De Pascale, Gianfranco; Fuller, John; Leeds, Jennifer A.; Reck, Folkert; Richie, Daryl L.; Vo, Jason; LaMarche, Matthew J.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3468 – 3475;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics