Synthetic Route of 210532-25-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 2; N-r5-( 4-Amino-7 -isopropvl-7 H-pvrrolor2 .3-dl pvrim idine-5-carbonvl)-pvrid in-3-vll-3,5- difluoro-benzenesulfonamide; 3,5-Difluoro-benzenesulfonyl chloride (19.7 mg, 0.093 mmol) was added to a solution of (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone (25 mg, 0.084 mmol) in pyridine (0.7 mL). The resulting solution was heated to 40 C for 16 h. The reaction mixture was concentrated in vacuo and the residue dissolved in DMSO (2 mL) and purified using reverse phase preparative HPLC to furnish the title compound as a white solid. MS: 473.2 (MH+) ; HPLC Rf: 4.91 min. (HPLC method 4).
The synthetic route of 3,5-Difluorobenzene-1-sulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/116035; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics