Application of 452-66-4,Some common heterocyclic compound, 452-66-4, name is 4-Chloro-1-fluoro-2-methylbenzene, molecular formula is C7H6ClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
41 g of acetyl chloride are added to 200 ml of 1,2-dichloroethane and 80 g of AlCl3 while cooling with ice. 72.3 g of 5-chloro-2-fluorotoluene are then added dropwise. The reaction mixture is warmed at 50 for 8 hours and then poured onto ice. The organic phase is washed with water, dried and distilled. Yield: about 50 g of 2-chloro-5-fluoro-4-methylacetophenone, boiling point10: 120-127.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-1-fluoro-2-methylbenzene, its application will become more common.
Reference:
Patent; Bayer Aktiengesellschaft; US4762844; (1988); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics