Some common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, molecular formula is C8H7ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks
Step 2. Synthesis of 3-(benzo[d][1 ,3]dioxol-5-ylmethyl)-5-(3-nitrobenzylidene)imidazo- lidine-2,4-dione; DBU (3.82 mmol, 0.961 g) is added into solution of 5-(3-nitrobenzylidene)imidazolidine-2,4- dione (3.19 mmol, 0.743 g) at O’O and the solution left to warm to room temperature. 5- (Chloromethyl)benzo[d][1 ,3]dioxole (6.37 mmol, 2.174 g, 50% soln in CH2CI2) is added and the reaction mixture stirred for 3 hours. Subsequently 0.5 M HCL solution is added and extracted with ethylacetate (2 x 50 ml_) dried over MgSO4 and the solvent removed under reduced pressure. The obtained product is recrystallized from diisopropylether to afford 0.13 (1 1%) of 3-(benzo[d][1 ,3]dioxol-5-ylmethyl)-5-(3-nitrobenzylidene)imidazo-lidine-2,4-dione.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20850-43-5, its application will become more common.
Reference:
Patent; LEK PHARMACEUTICAL D.D.; WO2008/43733; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics